Physiology and Anatomy Aware Inverse Inference of Myocardial Infarction for Cardiac Digital Twin

Accurate localization of myocardial infarction is essential for risk stratification. While LGE-MRI remains the gold standard, it is resource-intensive. Integrating cine MRI with ECG enables a more detailed representation of infarct properties. Existing inverse MI inference methods overlook realistic scar morphology and cardiac repolarization, reducing sensitivity to subtle ECG variations and interpretability of infarct-induced electrophysiological changes. In this paper, we propose a novel framework for noninvasive MI localization using cardiac digital twins. To bridge the domain gap between simulation and reality, we introduce an anatomy-aware stochastic infarct synthesis strategy to synthesize realistic, irregular scars with border zones, mimicking ischemic transmural progression. We then construct a virtual cohort to simulate QRS-T waveforms, capturing both depolarization and repolarization dynamics. Furthermore, we design a Physiology and Anatomy Aware Network (PAA-Net) that jointly encodes 3D myocardial geometry and multi-lead ECGs to infer infarct areas with varying localizations, sizes, spatial extents, and transmuralities. Experimental results demonstrate that our framework significantly outperforms existing methods in inverse inference, achieving Dice scores of 0.7391 and 0.5503 for scar and border zone segmentation, respectively, while further enhancing the interpretability of the ECG-infarct relationship. Our code will be released upon acceptance.

Text-to-CAD Retrieval: a Strong Baseline

Text-based retrieval of Computer-Aided Design (CAD) models is a critical yet underexplored task for the reuse of legacy industrial designs. Existing CAD repositories are typically searched using filenames or directories, which limits the efficiency, scalability, and accuracy of design retrieval. In this paper, we formally introduce text-to-CAD retrieval as a new cross-modal retrieval task, aiming to retrieve semantically relevant CAD models from large-scale databases given natural language queries. Leveraging paired text-CAD annotations from the Text2CAD dataset, we establish a practical benchmark for this task. To achieve text-based retrieval, we propose a unified framework that learns multi-modal CAD embeddings from both procedural sequences and geometric point clouds. Specifically, a sequence encoder captures the construction logic of CAD models, while a point encoder extracts explicit geometric features. A text encoder is used to learn semantic representations of textual queries. During training, we introduce a novel feature decoder that reconstructs masked sequence features via cross-attention with text and point features, encouraging implicit multi-modal alignment. At inference time, we remove this auxiliary decoder to enable efficient retrieval using concatenated sequence-point features. Our framework serves as a strong baseline for text-to-CAD retrieval and lays the foundation for downstream CAD generation paradigms, such as retrieval-augmented generation. The source code will be released.

Generative Data-engine Foundation Model for Universal Few-shot 2D Vascular Image Segmentation

The segmentation of 2D vascular structures via deep learning holds significant clinical value but is hindered by the scarcity of annotated data, severely limiting its widespread application. Developing a universal few-shot vascular segmentation model is highly desirable, yet remains challenging due to the need for extensive training and the inherent complexities of vascular imaging. In this work, we propose UniVG (Generative Data-engine Foundation Model for Universal Few-shot 2D Vascular Image Segmentation), a novel approach that learns the compositionality of vascular images and constructing a generative foundation model for robust vascular segmentation. UniVG enables the synthesis and learning of diverse and realistic vascular images through two key innovations: 1) Compositional learning for flexible and diverse vascular synthesis: It decomposes and recombines vascular structures with varying morphological features and diverse foreground-background configurations to generate richly diverse synthetic image-label pairs. 2) Few-shot generative adaptation for transferable segmentation: It fine-tunes pre-trained models with minimal annotated data to bridge the gap between synthetic and real vascular domains, synthesizing authentic and diverse vessel images for downstream few-shot vascular segmentation learning. To support our approach, we develop UniVG-58K, a large dataset comprising 58,689 vascular images across five imaging modalities, facilitating robust large-scale generative pre-training. Extensive experiments on 11 vessel segmentation tasks cross 5 modalties (only with 5 labeled images on each task) demonstrate that UniVG achieves performance comparable to fully supervised models, significantly reducing data collection and annotation costs. All code and datasets will be made publicly available at https://github.com/XinAloha/UniVG.

Multi-Condition Digital Twin Calibration for Axial Piston Pumps : Compound Fault Simulation

Axial piston pumps are indispensable power sources in high-stakes fluid power systems, including aerospace, marine, and heavy machinery applications. Their operational reliability is frequently compromised by compound faults that simultaneously affect multiple friction pairs. Conventional data-driven diagnosis methods suffer from severe data scarcity for compound faults and poor generalization across varying operating conditions. This paper proposes a novel multi-condition physics-data coupled digital twin calibration framework that explicitly resolves the fundamental uncertainty of pump outlet flow ripple. The framework comprises three synergistic stages: in-situ virtual high-frequency flow sensing on a dedicated rigid metallic segment, surrogate model-assisted calibration of the 3D CFD source model using physically estimated ripple amplitudes, and multi-objective inverse transient analysis for viscoelastic unsteady-friction pipeline parameter identification. Comprehensive experiments on a test rig demonstrate that the calibrated digital twin accurately reproduces both single-fault and two representative compound-fault. These results establish a high-fidelity synthetic fault-generation capability that directly enables robust zero-shot fault diagnosis under previously unseen operating regimes and fault combinations, thereby advancing predictive maintenance in complex hydraulic systems.

Reason-IAD: Knowledge-Guided Dynamic Latent Reasoning for Explainable Industrial Anomaly Detection

Industrial anomaly detection demands precise reasoning over fine-grained defect patterns. However, existing multimodal large language models (MLLMs), pretrained on general-domain data, often struggle to capture category-specific anomalies, thereby limiting both detection accuracy and interpretability. To address these limitations, we propose Reason-IAD, a knowledge-guided dynamic latent reasoning framework for explainable industrial anomaly detection. Reason-IAD comprises two core components. First, a retrieval-augmented knowledge module incorporates category-specific textual descriptions into the model input, enabling context-aware reasoning over domain-specific defects. Second, an entropy-driven latent reasoning mechanism conducts iterative exploration within a compact latent space using optimizable latent think tokens, guided by an entropy-based reward that encourages confident and stable predictions. Furthermore, a dynamic visual injection strategy selectively incorporates the most informative image patches into the latent sequence, directing the reasoning process toward regions critical for anomaly detection. Extensive experimental results demonstrate that Reason-IAD consistently outperforms state-of-the-art methods. The code will be publicly available at https://github.com/chenpeng052/Reason-IAD.

Multi-modal cross-domain mixed fusion model with dual disentanglement for fault diagnosis under unseen working conditions

Intelligent fault diagnosis has become an indispensable technique for ensuring machinery reliability. However, existing methods suffer significant performance decline in real-world scenarios where models are tested under unseen working conditions, while domain adaptation approaches are limited to their reliance on target domain samples. Moreover, most existing studies rely on single-modal sensing signals, overlooking the complementary nature of multi-modal information for improving model generalization. To address these limitations, this paper proposes a multi-modal cross-domain mixed fusion model with dual disentanglement for fault diagnosis. A dual disentanglement framework is developed to decouple modality-invariant and modality-specific features, as well as domain-invariant and domain-specific representations, enabling both comprehensive multi-modal representation learning and robust domain generalization. A cross-domain mixed fusion strategy is designed to randomly mix modality information across domains for modality and domain diversity augmentation. Furthermore, a triple-modal fusion mechanism is introduced to adaptively integrate multi-modal heterogeneous information. Extensive experiments are conducted on induction motor fault diagnosis under both unseen constant and time-varying working conditions. The results demonstrate that the proposed method consistently outperforms advanced methods and comprehensive ablation studies further verify the effectiveness of each proposed component and multi-modal fusion. The code is available at: https://github.com/xiapc1996/MMDG.

Digital Twin-Driven Zero-Shot Fault Diagnosis of Axial Piston Pumps Using Fluid-Borne Noise Signals

Axial piston pumps are crucial components in fluid power systems, where reliable fault diagnosis is essential for ensuring operational safety and efficiency. Traditional data-driven methods require extensive labeled fault data, which is often impractical to obtain, while model-based approaches suffer from parameter uncertainties. This paper proposes a digital twin (DT)-driven zero-shot fault diagnosis framework utilizing fluid-borne noise (FBN) signals. The framework calibrates a high-fidelity DT model using only healthy-state data, generates synthetic fault signals for training deep learning classifiers, and employs a physics-informed neural network (PINN) as a virtual sensor for flow ripple estimation. Gradient-weighted class activation mapping (Grad-CAM) is integrated to visualize the decision-making process of neural networks, revealing that large kernels matching the subsequence length in time-domain inputs and small kernels in time-frequency domain inputs enable higher diagnostic accuracy by focusing on physically meaningful features. Experimental validations demonstrate that training on signals from the calibrated DT model yields diagnostic accuracies exceeding 95\% on real-world benchmarks, while uncalibrated models result in significantly lower performance, highlighting the framework's effectiveness in data-scarce scenarios.

Enhancing Multimodal Protein Function Prediction Through Dual-Branch Dynamic Selection with Reconstructive Pre-Training

Multimodal protein features play a crucial role in protein function prediction. However, these features encompass a wide range of information, ranging from structural data and sequence features to protein attributes and interaction networks, making it challenging to decipher their complex interconnections. In this work, we propose a multimodal protein function prediction method (DSRPGO) by utilizing dynamic selection and reconstructive pre-training mechanisms. To acquire complex protein information, we introduce reconstructive pre-training to mine more fine-grained information with low semantic levels. Moreover, we put forward the Bidirectional Interaction Module (BInM) to facilitate interactive learning among multimodal features. Additionally, to address the difficulty of hierarchical multi-label classification in this task, a Dynamic Selection Module (DSM) is designed to select the feature representation that is most conducive to current protein function prediction. Our proposed DSRPGO model improves significantly in BPO, MFO, and CCO on human datasets, thereby outperforming other benchmark models.

Vad-R1: Towards Video Anomaly Reasoning via Perception-to-Cognition Chain-of-Thought

Recent advancements in reasoning capability of Multimodal Large Language Models (MLLMs) demonstrate its effectiveness in tackling complex visual tasks. However, existing MLLM-based Video Anomaly Detection (VAD) methods remain limited to shallow anomaly descriptions without deep reasoning. In this paper, we propose a new task named Video Anomaly Reasoning (VAR), which aims to enable deep analysis and understanding of anomalies in the video by requiring MLLMs to think explicitly before answering. To this end, we propose Vad-R1, an end-to-end MLLM-based framework for VAR. Specifically, we design a Perception-to-Cognition Chain-of-Thought (P2C-CoT) that simulates the human process of recognizing anomalies, guiding the MLLM to reason anomaly step-by-step. Based on the structured P2C-CoT, we construct Vad-Reasoning, a dedicated dataset for VAR. Furthermore, we propose an improved reinforcement learning algorithm AVA-GRPO, which explicitly incentivizes the anomaly reasoning capability of MLLMs through a self-verification mechanism with limited annotations. Experimental results demonstrate that Vad-R1 achieves superior performance, outperforming both open-source and proprietary models on VAD and VAR tasks. Codes and datasets will be released at https://github.com/wbfwonderful/Vad-R1.

Wavelet-based Global-Local Interaction Network with Cross-Attention for Multi-View Diabetic Retinopathy Detection

Multi-view diabetic retinopathy (DR) detection has recently emerged as a promising method to address the issue of incomplete lesions faced by single-view DR. However, it is still challenging due to the variable sizes and scattered locations of lesions. Furthermore, existing multi-view DR methods typically merge multiple views without considering the correlations and redundancies of lesion information across them. Therefore, we propose a novel method to overcome the challenges of difficult lesion information learning and inadequate multi-view fusion. Specifically, we introduce a two-branch network to obtain both local lesion features and their global dependencies. The high-frequency component of the wavelet transform is used to exploit lesion edge information, which is then enhanced by global semantic to facilitate difficult lesion learning. Additionally, we present a cross-view fusion module to improve multi-view fusion and reduce redundancy. Experimental results on large public datasets demonstrate the effectiveness of our method. The code is open sourced on https://github.com/HuYongting/WGLIN.